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KMID : 0861020120270050065
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Korea Journal of Herbology
2012 Volume.27 No. 5 p.65 ~ p.75
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Cosmeceutical Activities of Doinseunguitang and Its Composition
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Lee Jin-Young
Lee Soo-Yeon
Jun Hye-Ji
Yoon Ji-Young
Hwang Hyun-Uk
Park Joo-Hoon
An Bong-Jeun
Son Jun-Ho
Hwang Ju-Young
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Abstract
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Objectives: Cosmeceutical activities such as anti-oxidative and anti-aging effects of the Doinseunguitang and its composition, a traditional prescription, were evaluated.
Methods: We performed MTT assay, melanin synthesis inhibition assay, DPPH free radical scavenging assay, SOD-like activity, xanthine oxidase inhibition assay, astringent activity assay, tyrosinase inhibition assay, elastase and collagenase inhibition assay.
Results: The results were obtained as follows : DPPH free radical scavenging of water extract Doinseunguitang (DISG) and ethanol extract DISG was 60% and 50% at 1,000 ppm. Xanthine oxidase inhibition effect of ethanol extract showed more than 80% at 500 ppm. Tyrosinase inhibition and inhibition melanin synthesis activities were measured in 40% and 50% at 1,000 ppm and 100 ppm. Elastase and collagenase inhibition rate of ethanol extracts DISG 40% and 80% at 1,000 ppm. It was concluded that compositive ingredients (Persicae Seman, Glycyrrhizae Radix, Cinnamomi Ramulus, Rhei Rhizoma) influenced the most results.
Conclusions: The results indicated that, ethanol extract which is superior in its anti-oxidative and anti-aging effects is useful to be applied in herbal cosmetic industry.
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KEYWORD
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Doinseunguitang, anti-oxidant, anti-aging, herbal cosmetic, compositive ingredients
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